OPTIMIZATION OF INTER-CUBESAT COMMUNICATION LINKS

Cubesat constellations may become the next generation of communication backbone architecture to provide future worldwide communication services. In this thesis, we investigate the feasibility of deploying Cubesat constellations with inter-satellite links (ISL) for the delivery of continuous global communication. Cubesat constellation designs for various mission scenarios are proposed and verified using a simulation toolkit commonly used by space engineers. Link optimization to improve the overall theoretical data rate is also discussed. The results obtained affirm that a Cubesat constellation at an orbital height of 450 km can achieve a data rate of 11.46 kbps and requires the least number of satellites in the constellation. We ascertained that using ISL as the communication backbone in a network architecture, complete with space and globally distributed ground nodes, is achievable. In the near future, there is a high potential for the implementation of ISL with optical communication links, whereby there is assurance of a significantly higher data rate and lower power requirements.Civilian, Singapore Technologies ElectronicsApproved for public release; distribution is unlimited

Diagnostic prediction of complex diseases using phase-only correlation based on virtual sample template

Motivation: Complex diseases induce perturbations to interaction and regulation networks in living systems, resulting in dynamic equilibrium states that differ for different diseases and also normal states. Thus identifying gene expression patterns corresponding to different equilibrium states is of great benefit to the diagnosis and treatment of complex diseases. However, it remains a major challenge to deal with the high dimensionality and small size of available complex disease gene expression datasets currently used for discovering gene expression patterns. Results: Here we present a phase-only correlation (POC) based classification method for recognizing the type of complex diseases. First, a virtual sample template is constructed for each subclass by averaging all samples of each subclass in a training dataset. Then the label of a test sample is determined by measuring the similarity between the test sample and each template. This novel method can detect the similarity of overall patterns emerged from the differentially expressed genes or proteins while ignoring small mismatches. Conclusions: The experimental results obtained on seven publicly available complex disease datasets including microarray and protein array data demonstrate that the proposed POC-based disease classification method is effective and robust for diagnosing complex diseases with regard to the number of initially selected features, and its recognition accuracy is better than or comparable to other state-of-the-art machine learning methods. In addition, the proposed method does not require parameter tuning and data scaling, which can effectively reduce the occurrence of over-fitting and bias

Molecular cancer classification using an meta-sample-based regularized robust coding method

Motivation Previous studies have demonstrated that machine learning based molecular cancer classification using gene expression profiling (GEP) data is promising for the clinic diagnosis and treatment of cancer. Novel classification methods with high efficiency and prediction accuracy are still needed to deal with high dimensionality and small sample size of typical GEP data. Recently the sparse representation (SR) method has been successfully applied to the cancer classification. Nevertheless, its efficiency needs to be improved when analyzing large-scale GEP data. Results In this paper we present the meta-sample-based regularized robust coding classification (MRRCC), a novel effective cancer classification technique that combines the idea of meta-sample-based cluster method with regularized robust coding (RRC) method. It assumes that the coding residual and the coding coefficient are respectively independent and identically distributed. Similar to meta-sample-based SR classification (MSRC), MRRCC extracts a set of meta-samples from the training samples, and then encodes a testing sample as the sparse linear combination of these meta-samples. The representation fidelity is measured by the l2-norm or l1-norm of the coding residual. Conclusions Extensive experiments on publicly available GEP datasets demonstrate that the proposed method is more efficient while its prediction accuracy is equivalent to existing MSRC-based methods and better than other state-of-the-art dimension reduction based methods.This article was funded by the National Science Foundation of China on finding tumor-related driver pathway with comprehensive analysis method based on next-generation sequencing data and the dimension reduction of gene expression data based on heuristic method (grant nos. 61474267, 60973153 and 61133010) and the National Institutes of Health (NIH) Grant P01 AG12993 (PI: E. Michaelis). This article has been published as part of BMC Bioinformatics Volume 15 Supplement 15, 2014: Proceedings of the 2013 International Conference on Intelligent Computing (ICIC 2013). The full contents of the supplement are available online at http://www.biomedcentral.com/bmcbioinformatics/supplements/15/S15

Finding minimum gene subsets with heuristic breadth-first search algorithm for robust tumor classification

Background: Previous studies on tumor classification based on gene expression profiles suggest that gene selection plays a key role in improving the classification performance. Moreover, finding important tumor-related genes with the highest accuracy is a very important task because these genes might serve as tumor biomarkers, which is of great benefit to not only tumor molecular diagnosis but also drug development. Results: This paper proposes a novel gene selection method with rich biomedical meaning based on Heuristic Breadth-first Search Algorithm (HBSA) to find as many optimal gene subsets as possible. Due to the curse of dimensionality, this type of method could suffer from over-fitting and selection bias problems. To address these potential problems, a HBSA-based ensemble classifier is constructed using majority voting strategy from individual classifiers constructed by the selected gene subsets, and a novel HBSA-based gene ranking method is designed to find important tumor-related genes by measuring the significance of genes using their occurrence frequencies in the selected gene subsets. The experimental results on nine tumor datasets including three pairs of cross-platform datasets indicate that the proposed method can not only obtain better generalization performance but also find many important tumor-related genes. Conclusions: It is found that the frequencies of the selected genes follow a power-law distribution, indicating that only a few top-ranked genes can be used as potential diagnosis biomarkers. Moreover, the top-ranked genes leading to very high prediction accuracy are closely related to specific tumor subtype and even hub genes. Compared with other related methods, the proposed method can achieve higher prediction accuracy with fewer genes. Moreover, they are further justified by analyzing the top-ranked genes in the context of individual gene function, biological pathway, and protein-protein interaction network. Keywords: Gene expression profiles; Gene selection; Tumor classification; Heuristic breadth-first search; Power-law distributio

Finding minimum gene subsets with heuristic breadth-first search algorithm for robust tumor classification

Background: Previous studies on tumor classification based on gene expression profiles suggest that gene selection plays a key role in improving the classification performance. Moreover, finding important tumor-related genes with the highest accuracy is a very important task because these genes might serve as tumor biomarkers, which is of great benefit to not only tumor molecular diagnosis but also drug development. Results: This paper proposes a novel gene selection method with rich biomedical meaning based on Heuristic Breadth-first Search Algorithm (HBSA) to find as many optimal gene subsets as possible. Due to the curse of dimensionality, this type of method could suffer from over-fitting and selection bias problems. To address these potential problems, a HBSA-based ensemble classifier is constructed using majority voting strategy from individual classifiers constructed by the selected gene subsets, and a novel HBSA-based gene ranking method is designed to find important tumor-related genes by measuring the significance of genes using their occurrence frequencies in the selected gene subsets. The experimental results on nine tumor datasets including three pairs of cross-platform datasets indicate that the proposed method can not only obtain better generalization performance but also find many important tumor-related genes. Conclusions: It is found that the frequencies of the selected genes follow a power-law distribution, indicating that only a few top-ranked genes can be used as potential diagnosis biomarkers. Moreover, the top-ranked genes leading to very high prediction accuracy are closely related to specific tumor subtype and even hub genes. Compared with other related methods, the proposed method can achieve higher prediction accuracy with fewer genes. Moreover, they are further justified by analyzing the top-ranked genes in the context of individual gene function, biological pathway, and protein-protein interaction network. Keywords: Gene expression profiles; Gene selection; Tumor classification; Heuristic breadth-first search; Power-law distributio

Design and Implementation WiMAX Transceiver on Multicore Platform

Before we design the WiMAX Base Station (BS), three questions we should answered. The first is what kind of system parameters will be selected? The second is which platform will be used for the BS design. And the third one is which algorithm will be selected for some modules that are not defined in 16e standard, especially for the receiver modules, such as synchronization, channel estimation, and STC (Space Time Coding) decoder, etc. When all the above questions obtain proper answers, we can start the BS design and implementation on specific platform to achieve aimed system performance. In this chapter, we will focus on the PHY (physical Layer) design of WiMAX BS

RAI-Net: Range-Adaptive LiDAR Point Cloud Frame Interpolation Network

LiDAR point cloud frame interpolation, which synthesizes the intermediate frame between the captured frames, has emerged as an important issue for many applications. Especially for reducing the amounts of point cloud transmission, it is by predicting the intermediate frame based on the reference frames to upsample data to high frame rate ones. However, due to high-dimensional and sparse characteristics of point clouds, it is more difficult to predict the intermediate frame for LiDAR point clouds than videos. In this paper, we propose a novel LiDAR point cloud frame interpolation method, which exploits range images (RIs) as an intermediate representation with CNNs to conduct the frame interpolation process. Considering the inherited characteristics of RIs differ from that of color images, we introduce spatially adaptive convolutions to extract range features adaptively, while a high-efficient flow estimation method is presented to generate optical flows. The proposed model then warps the input frames and range features, based on the optical flows to synthesize the interpolated frame. Extensive experiments on the KITTI dataset have clearly demonstrated that our method consistently achieves superior frame interpolation results with better perceptual quality to that of using state-of-the-art video frame interpolation methods. The proposed method could be integrated into any LiDAR point cloud compression systems for inter prediction.Comment: Accepted by the IEEE International Symposium on Broadband Multimedia Systems and Broadcasting 202